Neurological deterioration or symptom progression in Wilson’s disease after starting zinc sulphate treatment - a case report
نویسندگان
چکیده
Wilson’s disease (WD) is an inherited autosomal recessive disorder that lead to copper accumulation in the liver, brain, cornea, and other organs [1]. WD is treatable by life-long decoppering therapy with the aim of removing excess copper and preventing re-accumulation. This is accomplished with two main groups of drugs: chelating agents, including d-penicillamine (DPA) and trientine, that promote urinary excretion of copper; and zinc salts, including zinc sulphate (ZS), that interfere with intestinal uptake of copper [1].
منابع مشابه
Withdrawal of penicillamine from zinc sulphate-penicillamine maintenance therapy in Wilson's disease: promising, safe and cheap.
BACKGROUND Penicillamine, once considered the cornerstone of treatment for Wilson disease (WD), is rather expensive and toxic, and often causes neurological worsening. Zinc sulphate, aiming at the treatment of free-copper toxicosis, has emerged as effective, safe and cheap alternative. AIM To assess the effect of withdrawal of penicillamine from maintenance treatment with penicillamine and zi...
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